D2R Runes and the Rune Words created by combining them are a crucial component of the arsenal in Diablo 2: Resurrected. In 2001, the expansion Lord of Destruction introduced runes and Rune Words to Diablo 2, adding a fifth act and completely transforming the game with the addition of runes. The most coveted runes can also serve as a form of currency for trading top-tier items. Diablo 2...