Wellness for Life Blog | Can Weed Cause Acne? If your skin breaks out after smoking weed, you're not alone. THC may increase oil production or affect hormones, triggering acne in some users. Wellness for Life Blog explains how cannabis interacts with your skin and what you can do to avoid breakouts. Discover expert-backed skincare strategies made for real users like you. Find out how to manage your acne while staying informed.